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[sixty one] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, and that is fewer powerful being an opioid, is a lot more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone features a lower affinity, w